Ambitions (yes, we’re ambitious …)
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This very first page is a good place to mention our ambitions here at the Division of Medicinal Chemistry of Leiden University. We want to understand drug action at ‘high resolution’, thus at an almost atomic level. We want to use that understanding for a more rational approach of drug design. We have chosen the most important class of drug targets to work on, the G protein-coupled receptors (GPCRs). Close to 30% of all medicines work via these targets in our body.

Well, one can’t study all receptors, as there are over 800 of them in the human body. So, we have selected a few to concentrate on, receptors for adenosine, for cannabinoids, for chemokines and a few more. We pursue a ‘chemical biology’ approach, in which we combine synthetic chemistry, new developments in the world of informatics and computer science (bioinformatics, cheminformatics), and both biochemistry/molecular biology and pharmacology. That is quite ideal, as we now have in one hand all ingredients to come up with ideas for new drugs, make them, and see how they work.

Why don’t you read more about the fascinating four adenosine receptors? One may help to cure Parkinson’s disease, most are involved in the actions of caffeine…


Julia Hillger wins first prize during FIGON PhD poster competition
Julia Hillger wins first prize with FIGON PhD poster competition

Drs. Julia Hillger won the first prize for the category "signal transduction" during the PhD poster presentation competition at the FIGON Dutch Medicine Days, October 5th 2015.

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Dr. Gerard van Westen receives VENI grant
Gerard van Westen

Gerard van Westen (LACDR/division of medicinal chemistry) has been awarded with a VENI grant from NWO, the Dutch Research Council.

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Laura Groen attends STeLA forum
Laura Groen

Laura Groen, MSc student at LACDR’s division of medicinal chemistry, has been elected to attend the Science and Technology Leadership Assocation (STeLA) forum.

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Prof.dr. Ad IJzerman appointed as Secretary of The Royal Holland Society of Sciences and Humanities
Ad IJzerman

As of May 2015, Prof. dr. Ad Ijzerman has been appointed as Secretary of The Royal Holland Society of Sciences and Humanities.

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